The Multifaceted Nature of Immunoglobulin A and Its Complex Role in HIV

E Lopez; RJ Shattock; SJ Kent; AW Chung

Journal article

The Multifaceted Nature of Immunoglobulin A and Its Complex Role in HIV

E Lopez, RJ Shattock, SJ Kent, AW Chung

AIDS Research and Human Retroviruses | MARY ANN LIEBERT, INC | Published : 2018

DOI: 10.1089/aid.2018.0099

Abstract

IgA is the most abundant immunoglobulin in mucosal secretions, and understanding the role of IgA in both protection from HIV acquisition and modulation of HIV disease progression is a field of considerable controversy and renewed research interest. Analysis of the RV144 clinical trial associated plasma HIV envelope-specific monomeric IgA from vaccines with reduced vaccine efficacy. The RV144 trial, however, only assessed for plasma IgA, which was not further subclassed, and the role of mucosal IgA was not addressed as mucosal samples were not collected. On the other hand, several studies have detected envelope-specific IgA in mucosal secretions of highly exposed persistently seronegative coh..

View full abstract

University of Melbourne Researchers

Stephen Kent Author

Amy Chung Author

Related Projects (4)

IMPROVED HIV AND INFLUENZA VACCINES

This fellowship is to support Professor Stephen Kent in generating new advances in vaccines to prevent HIV (the cause of AIDS) and Influenza..

SYTEMIC AND MUCOSAL FUNCTIONAL ANTIBODIES IN PROTECTION AGAINST HIV

Only one human HIV vaccine has shown any level of protective efficacy. However the mechanisms behind how this vaccine was protective are sti..

EUROPEAN AIDS VACCINE INITIATIVE 2020

A vaccine to prevent AIDS is urgently needed. The European Union recently awarded over 20 million euros to a European consortium, called EAV..

HIV LATENCY PATHOGENESIS AND IMMUNITY

The development of cures, vaccines and better treatments for HIV/AIDS is an urgent global health priority. This team of seven groups in Sydn..

Grants

Awarded by Horizon 2020 Framework Programme

Funding Acknowledgements

This work was supported by an American Foundation for AIDS Research (amfAR) Mathilde Krim Fellowship (109499-61-RKVA to A.W.C.), Australian NHMRC awards 1052979, 1125164, 1115828, and 1136322, and the European Union Horizon 2020 Research and Innovation Programme under grant agreement no. 681137.